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Extracted from bovine bulbus arteriosus, Desmosine and lsodesmosine content as high as 0.37%
Effects on skin:
1. Promotion of collagen production
2. Activating effect on human dermal fibroblasts
3. Promotion of elastin production
Effect on endothelial cell：
Promoting effect proliferation of endothelial cell => improving environment of intima
Promoting effect on promotion oft-PA=> Promoting thrombolysis
Suppressing effect on production of ET-1 =>suppressing shrinkage of BV
Effect on smooth musclle cell：
Suppressing effect on proliferation of smooth muscle cell
=>Suppressing thickening ofintima and media
Others：
Suppressing effect on platelet aggregation=>Suppressing effect on clot formation
Roles of Elastin in Ligament：
Promoting cell proliferation: lmproving ligament function
Expressing collagen/elastin: lmproving ligament function
Suppressing differentiation of bone
Suppressing ossification of ligament
